Recurrence of hepatocellular carcinoma after liver transplantation: Isolated splenic metastasis

Abstract

Despite strict selection criteria for transplantation, relapse of disease after transplantation is observed. With the improvement in survival following treatment and advances in patient monitoring and management, extrahepatic metastases have gained increasing clinical significance. Extrahepatic hepatocellular carcinoma (HCC) recurrences are usually observed in the lungs, lymph nodes, bones, and adrenal glands. The spleen has been reported rarely as a metastatic site of HCC. There is no consensus for the management of HCC recurrence after liver transplantation. Surgical resection is usually the first choice of treatment because curative-intent treatments have better survival. In this case report, we will share a rare splenic recurrence in a patient who underwent liver transplantation due to HCC.