Lemborexant: mechanism, efficacy, and clinical implications

Abstract

Lemborexant, a dual orexin receptor antagonist (DORA), has emerged as an effective treatment for insomnia by modulating the orexin signalling pathway, which is critical in maintaining wakefulness. This review explores lemborexant’s mechanism of action, clinical efficacy, pharmacokinetic profile, safety, and tolerability in treating sleep disorders, with a focus on insomnia. Through a synthesis of recent clinical trials and comparative studies, this article provides a comprehensive view of lemborexant’s therapeutic role and potential in addressing the unmet needs of patients with sleep disturbances.