Cardiorenal effects of SGLT2 inhibitors: who might benefit?


  • E Klug Netcare Sunninghill
  • B Rayner Groote Schuur Hospital
  • M Wasserman Mediclinic Panorama
  • A Kok Netcare Alberton Hospital
  • M Mpe Mediclinic Heart Hospital
  • S Ruder Life Healthcare
  • NH Mohamed University of the Witwatersrand
  • D Webb Houghton House Addiction & Mental Health Treatment Centres


cardiovascular disease, high risk, renal disease, secondary prevention, SGLT2 inhibitors


Sodium glucose co-transporter-2 inhibitors have been shown to have multiple cardiovascular and renal benefits in patients with type 2 diabetes. In large randomised controlled trials they reduced major cardiovascular outcomes, hospitalisation for heart failure and adverse kidney outcomes, independently of their glucose-lowering effects. They are simple to prescribe and do not require dose titration. Compelling indications for this class of medications in patients with type 2 diabetes include those at high or very high risk of cardiovascular events and those with established atherosclerotic cardiovascular disease. They are also indicated for patients with heart failure and chronic kidney disease, regardless of diabetic status.

Author Biographies

E Klug, Netcare Sunninghill

Netcare Sunninghill and Sunward Park Hospitals, Division of Cardiology, Charlotte Maxeke Johannesburg Academic Hospital, South Africa

B Rayner, Groote Schuur Hospital

Division of Nephrology and Hypertension, Groote Schuur Hospital, South Africa

M Wasserman, Mediclinic Panorama

Mediclinic Panorama, South Africa

A Kok, Netcare Alberton Hospital

Netcare Alberton Hospital, South Africa

M Mpe, Mediclinic Heart Hospital

Mediclinic Heart Hospital, South Africa

S Ruder, Life Healthcare

Life Healthcare, South Africa

NH Mohamed, University of the Witwatersrand

Division of Endocrinology, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, South Africa

D Webb, Houghton House Addiction & Mental Health Treatment Centres

Houghton House Addiction & Mental Health Treatment Centres, South Africa