The link between thyroid hormones and cutaneous squamous cell carcinoma

Abstract

This case study aims to improve clinical practice by highlighting hypothyroidism as a possible risk factor for the development of squamous cell carcinoma (SCC), particularly in people of colour. A 65-year-old Black female presented with generalised weakness and confusion. Examination revealed a left-sided oculomotor nerve palsy. Laboratory tests indicated central hypothyroidism with a CT brain scan showing a cystic lesion in the suprasellar region. Patient history revealed that a malignant growth had been excised from her left leg eight months earlier and biopsy results revealed SCC. This case study underlines the connection between hypothyroidism and SCC, emphasising the complex role of thyroid hormones in cancer development.